Endocrine Abstracts

The long-term effects of an acute stress on subsequent HPA axis activity are well established. We have investigated the effects of different acute stressors on HPA activity, and the severity of inflammation in the rat model of adjuvant-induced arthritis (AA). A single injection of LPS administered to neonates can protect these rats from developing inflammation in response to adjuvant injection as adults. Similarly, LPS given to adults 3 weeks prior to adjuvant injection can pr...

Enhanced corticosterone release by female compared to male rats under basal and stress conditions has been frequently evidenced (1). The demonstration that gonadectomy enhances stress-induced corticosterone secretion in male rats (2) but reduces such levels in female rats (3) suggests a causal association between gonadal steroids and corticosterone release. The present study examined the corticosterone profile of intact and gonadectomised female and male rats under basal and s...